| Views: 506 |
| Date: 29 Jan 2012 |
|
|
|
Definition of medical terminology for Food.
A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell.
Definition of medical terminology for Risk.
Definition of medical terminology for Progressive Multifocal Leukoencephalopathy.
Definition of medical terminology for Brain.
Definition of medical terminology for Infection.
Definition of medical terminology for Multiple Sclerosis.
Definition of medical terminology for Sclerosis.
Definition of medical terminology for Disease.
Definition of medical terminology for Body Build.
Definition of medical terminology for Forms.
Definition of medical terminology for Multiple Sclerosis.
Definition of medical terminology for Sclerosis.
Definition of medical terminology for Disease.
Definition of medical terminology for Risks.
Definition of medical terminology for Patients.
An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
Definition of medical terminology for Risk.
Definition of medical terminology for Patients.
Definition of medical terminology for Risk.
Definition of medical terminology for Risk.
Definition of medical terminology for Risk.
In anatomy, one of the two layers of compact bone
Definition of medical terminology for Risk.
In anatomy, one of the two layers of compact bone
An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
Definition of medical terminology for Healthcare.
Definition of medical terminology for Professional Activity Studies.
An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
Enzyme-linked immunosorbent assay
Definition of medical terminology for Person.
Definition of medical terminology for Past Trend.
Definition of medical terminology for Brain.
Definition of medical terminology for Nerve Fibers.
A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell.
Definition of medical terminology for Systems Agencies, Health.
Definition of medical terminology for Human Immunodeficiency Virus.
A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell.
Definition of medical terminology for Leukemia.
PML is a rare but serious brain infection associated with use of Tysabri (natalizumab) for the treatment of multiple sclerosis (MS) or Crohn`s disease.
Facts about Tysabri (natalizumab)
In a class of medications called immunomodulators. It works by stopping certain cells of the immune system from causing damage to the body .
Has been approved by the FDA for the treatment of relapsing forms of multiple sclerosis since November 2004 and for the treatment of moderately to severely active Crohn`s disease since January 2008.
The risks and benefits of continuing treatment with Tysabri should be carefully considered in patients who are found to be anti-JCV antibody positive and have one or more of the other known risk factors for PML. Patients with all three known risk factors have an estimated risk of PML of 11/1,000 users. The risk factors are:
The presence of anti-JCV antibodies.
Longer duration of Tysabri treatment, especially beyond 2 years.
Prior treatment with an immunosuppressant medication (e.g., mitoxantrone, azathioprine, methotrexate, cyclophosphamide, or mycophenolate mofetil).
The drug label for Tysabri has been revised to reflect this updated information including a table estimating the rate of PML stratified by the three known risk factors (see Table 1 below).
A patient`s anti-JCV antibody status may be determined using an anti-JCV antibody detection test that has been analytically and clinically validated, and has been ordered by a healthcare professional . The Stratify JCV Antibody ELISA test was cleared by FDA on January 20, 2012. Testing positive for anti-JCV antibodies means that a person has been exposed to JCV in the past .
PML is a rare disorder in which the coating (myelin) of some brain nerve fibers gets damaged. Although JCV is a common virus that is generally harmless and does not cause symptoms in people whose immune systems function normally, it can cause PML in people with weakened immune systems . Causes of a weakened immune system may include human immunodeficiency virus (HIV) infection, leukemia or lymphoma, or taking a medication such as Tysabri.
Source :
DrugsFreeList.com
Tags:
myelin, Tysabri, natalizumab, brain infection, progressive multifocal leukoencephalopathy
|
