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FDA approves Voraxaze to treat patients with toxic methotrexate levels

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Date: 19 Jan 2012
Definition of medical terminology for Food.
Definition of medical terminology for Patients.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Kidney Failure.
Definition of medical terminology for Failure Analyses, Equipment.
The U.S. Food and Drug Administration approved Voraxaze (glucarpidase) to treat patients with toxic levels of methotrexate in their blood due to kidney failure .

Definition of medical terminology for Patients.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Kidney Failure.
Definition of medical terminology for Failure Analyses, Equipment.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Body Build.
A blood vessel that carries blood low in oxygen content from the body back to the heart.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Death.
Definition of medical terminology for Hematology.
Definition of medical terminology for Drug Evaluation.
Definition of medical terminology for Evaluation.
Definition of medical terminology for Research.
Definition of medical terminology for Patients.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Orphan.
Definition of medical terminology for Disease.
Definition of medical terminology for Populations.
Definition of medical terminology for Patients.
Definition of medical terminology for Patients.
Definition of medical terminology for Treatment Associated Cancer.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Patients.
Definition of medical terminology for Standard of Living.
Definition of medical terminology for Patients.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Patients.
Definition of medical terminology for Safety.
Definition of medical terminology for Patients.
Definition of medical terminology for Methotrexate.
Definition of medical terminology for Blood Air Barrier.
Definition of medical terminology for Patients.
Definition of medical terminology for Blood Pressure.
Not normal.
Definition of medical terminology for Sensation.

Methotrexate is a commonly used cancer chemotherapy drug normally eliminated from the body by the kidneys. However, patients receiving high doses of methotrexate may develop kidney failure .

Voraxaze is an enzyme that rapidly reduces methotrexate levels by breaking the chemotherapy drug down to a form that can be eliminated from the body . Voraxaze is administered directly into a patientas vein (intravenously).

aProlonged exposure to high levels of methotrexate can result in kidney and liver damage, severe mouth sores, damage to the lining of the intestine, skin rashes, and death due to low blood counts,a said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDAas Center for Drug Evaluation and Research. aVoraxaze is an important new treatment option for cancer patients aimed at preventing these toxicities associated with sustained high levels of methotrexate.a

Voraxaze has an orphan drug designation, given to therapies indicated for rare or specific disease populations.

A single clinical study of 22 patients evaluated the effectiveness of Voraxaze. All patients received Voraxaze treatment . The study considered treatment a success if the methotrexate level fell below a critical level within 15 minutes and stayed below the critical level for eight days. Ten of the 22 patients achieved this standard . Although not all patients experienced this result, Voraxaze eliminated 95 percent of the methotrexate in all patients.

A separate clinical study evaluated the safety of Voraxaze in 290 patients experiencing problems clearing methotrexate from their blood .

The most common side effects observed in greater than one percent of patients in the clinical study were low blood pressure (hypotension), headache, nausea, vomiting, flushing, and abnormal sensation (paraesthesia).

Voraxaze is marketed by BTG International Inc., West Conshohocken, Pa.


Source : DrugsFreeList.com
Tags: methotrexate, Voraxaze, cancer chemotherapy drug, glucarpidase

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