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  E Box Sites

Medical Dictionary
Definition of medical terminology for E Box Sites.
DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS (GENETICS) may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.

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